COMPARISON AND EVALUATION OF MARKETED ACECLOFENAC TABLETS

INTRODUCTION

Aceclofenac belongs to a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). It works by blocking the action of a substance in the body called cyclooxygenase. Cyclooxygenase is involved in the production of various chemicals in the body, some of which are known as prostaglandins. Prostaglandins are produced in response to injury or certain diseases and would otherwise go on to cause pain, swelling and inflammation. Ankylosing spondylitis, orthritic conditions are example of this medicines in this group reduce inflammation caused by the body’s own immue system and are effective pain killers.

Warning given for this drug:
This medicine may cause dizziness, so avoiding driving and operating machinery. Individuals receiving long-term treatment with medicine should be regularly monitored (kidney and liver function tests, blood counts).

Used with caution in a type of life inherited blood disease caused by a defect in the liver (hepatic prophyria.)
v Bleeding tendencies
v Blood disorders
v Crohn’s disease
v Decreased heart function
v Elderly people
v History of peptic ulcers
v Inflammation of the bowel and back passage
v Middly decreased kidney function
v People who have recently had major surgery
v People who have recently had major surgery
v People with symptoms of stomach or intestinal disorders
v Severly decreased liver function
v Active peptic ulcer
v Bleeding from the stomach or intestines
v Moderate to severely decreased kidney function
v People in whom aspirin or other medicines in this class (NSAIDs), cause attacks of asthma, itchyrash (utricaria) or nasal inflammation (rhinitis) suspected peptic ulcer.
During pregnancy and Breastfeeding
Certain medicines should not be used however, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigth the risks to the unborn baby.
Label warnings for this drug
Take this medication with or after food.
DRUG PROFILE





Molecular Formula : C16H13Cl12NO4
Molecular Weight : 354.2
IUPAC Name : [2,4 – Dichloropheny1 amino]
Phenyl acetoxy acetic acid

MECHANISM ACTION

1. Aceclofenac directly blocks PGE 2 at the site of inflammation by inhibiting IL-Beta & TNF in the inflammatory cells (Intracellular Action). Aceclofenac has been demonstrated to inhibit cyclooxygenase (COX)